Systemic sclerosis & Raynaud's
Quantitative 18F-FDG PET-CT can assess presence and extent of interstitial lung disease in early severe diffuse cutaneous systemic sclerosis
Authors' conclusion
18F-FDG PET-CT can detect metabolic activity in the lungs of patients with early severe diffuse cutaneous SSc and ILD, correlating with higher ILD extent (≥ 20%) and lower DLCO%.
Study context
- Population
- Patients with early severe diffuse cutaneous systemic sclerosis (SSc) with and without interstitial lung disease (ILD), and controls without SSc
- Participants
- 15 / 5 / 7
- Exposure
- SSc-ILD vs SSc without ILD vs controls without SSc
- SSc-ILDn = 15
- SSc without ILDn = 5
- Controlsn = 7reference
- Outcome
- Quantitative 18F-FDG PET-CT lung uptake
Methodological detailsprospective
- Prospective
Main finding
As reported in the abstract
18F-FDG uptake in dorsobasal lung fields
- SSc-ILD vs SSc without ILD: P = 0.03
- SSc-ILD vs Controls: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| 18F-FDG uptake by ILD extent (≥ 20% vs < 20%)Uptake higher with extensive ILD | P = 0.04 |
Correlation of 18F-FDG uptake with DLCO%
- Spearman R with DLCO% (p = 0.02)
- −0.59
High-resolution computed tomography (HRCT) abnormalities
- Ground-glass opacities, with or without reticulation, corresponded to increased 18F-FDG uptake
Original publication
Quantitative 18F-FDG PET-CT can assess presence and extent of interstitial lung disease in early severe diffuse cutaneous systemic sclerosis. Arthritis Res Ther. Published 19 December 2024. doi:10.
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