Systemic sclerosis & Raynaud's
Elevated Fcy receptor expression augments pro-inflammatory macrophage phagocytosis in systemic sclerosis and associated rheumatic diseases
Authors' conclusion
This study highlights FcγR-expressing macrophages as drivers of phagocytosis and inflammatory responses in SSc.
Study context
- Population
- Skin and lung macrophages (Single-cell RNA sequencing (scRNA-seq) datasets) and monocyte-derived macrophages from healthy controls (HC) and patients with SSc, RA, PsA and axSpA
- Comparison
- Macrophages from SSc, RA, PsA and axSpA patients vs HC; nintedanib pretreatment
- Outcome
- Macrophage phagocytic phenotype
Methodological detailsscRNA-seq dataset analysis, in vitro hMDM experiments
- scRNA-seq dataset analysis
- In vitro hMDM experiments
Main finding
As reported in the abstract
- Pro-phagocytic signature in SSc-affected organs on scRNA-seq
- SSc macrophages, particularly FCGR3Ahi skin cluster: elevated FCGR gene expression and enriched FcγR-mediated phagocytosis pathways, with pro-inflammatory markers
- Phenotype extended to FCN1hi lung macrophages in SSc with ILD
- Human monocyte-derived macrophages (hMDMs) from SSc, RA and PsA patients: enhanced phagocytic activity in vitro
- Elevated FcγRI and FcγRII levels identified as key drivers of increased phagocytosis and subsequent IL-6-driven inflammation
- Nintedanib (0.1 μM) reduced FcγRI expression
Original publication
Elevated Fcy receptor expression augments pro-inflammatory macrophage phagocytosis in systemic sclerosis and associated rheumatic diseases. Rheumatology (Oxford). Published 13 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →