Systemic sclerosis & Raynaud's
A Strong Dysregulated Myeloid Component in the Epigenetic Landscape of Systemic Sclerosis: An Integrated DNA Methylome and Transcriptome Analysis
Authors' conclusion
Our findings uncover the impaired epigenetic regulation of the disease and its impact on gene expression, identifying new molecules for potential clinical applications and improving our understanding of SSc pathogenesis.
Study context
- Population
- Patients with systemic sclerosis (SSc) and unaffected individuals; whole-blood samples
- Participants
- 179 vs 241
- Comparison
- Patients with SSc vs unaffected individuals
- SScn = 179
- Unaffected individualsn = 241reference
- Outcome
- Differentially methylated positions (DMPs) with FDR <0.05
Methodological detailswhole-blood DNA methylation, integrated RNA sequencing, false discovery rate (FDR) <0.05
- Whole-blood DNA methylation
- Integrated RNA sequencing
- FDR <0.05
Main finding
As reported in the abstract
DMPs associated with SSc
Differentially methylated positions (DMPs) identified, enriched in immune-related pathways
525
Most significant pathway: leukocyte cell-cell adhesion (FDR)
4.91 × 10-9
Original publication
A Strong Dysregulated Myeloid Component in the Epigenetic Landscape of Systemic Sclerosis: An Integrated DNA Methylome and Transcriptome Analysis. Arthritis Rheumatol. Published 12 December 2024. doi:10.
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