Systemic sclerosis & Raynaud's
Dysregulation of circulating collagen turnover markers in very early systemic sclerosis
Authors' conclusion
These findings indicate ECM remodelling as a very early phenomenon of SSc occurring in parallel with microvascular and autoimmune changes.
Study context
- Population
- Patients with very early systemic sclerosis (SSc) without clinically detectable fibrosis, and healthy controls
- Participants
- 42 vs 29
- Exposure
- Very early SSc vs healthy controls
- veSScn = 42
- Healthy controls (HCs)n = 29reference
- Outcome
- Serum extracellular matrix (ECM) degradation (BGM, C3M, C4M, C6M) and formation (PRO-C3, PRO-C4, PRO-C5) biomarkers measured by ELISA
Methodological detailscross-sectional analysis at baseline, longitudinal analysis
- Cross-sectional analysis at baseline
- Longitudinal analysis
Main finding
As reported in the abstract
ECM turnover biomarkers, veSSc vs HC · baseline
- veSSc vs HCs: P < 0.0001
- veSSc vs HCs: P < 0.0001
- veSSc vs HCs: P = 0.004
- veSSc vs HCs: P < 0.0001
- veSSc vs HCs: P < 0.0001
- veSSc vs HCs: P = 0.006
- veSSc vs HCs: P = 0.002
Observational data: associations, not effects.
Further findings
Discrimination of veSSc vs HC (ROC analysis)
- C3M AUC (p<0.0001)
- 0.95
- C4M AUC (p<0.0001)
- 0.97
- PRO-C3/C3M AUC (p<0.0001)
- 0.80
- PRO-C4/C4M AUC (p<0.0001)
- 0.97
Original publication
Dysregulation of circulating collagen turnover markers in very early systemic sclerosis. RMD Open. Published 28 May 2024. doi:10.
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