Systemic sclerosis & Raynaud's
Dystrophic calcinosis: structural and morphological composition, and evaluation of ethylenediaminetetraacetic acid (‘EDTA’) for potential local treatment
Authors' conclusion
Stone and paste calcium-based deposits both comprise hydroxyapatite, but the constituent crystals vary in size and morphology. Hydroxyapatite is the only crystalline polymorph present in the SSc-related calcinosis deposits. Hydroxyapatite can be dissolved in vitro using a dosage of EDTA considered safe for clinical application.
Study context
- Population
- Calcium-based (calcinosis) deposits retrieved from subjects with SSc
- Comparison
- Stone vs Paste
- Outcome
- Composition, morphology and EDTA dissolution of calcinosis deposits
Methodological detailsin vitro
- In vitro
Main finding
As reported in the abstract
Deposits effectively dissolved in vitro with aqueous EDTA solution
3%
Complete dissolution of both deposit types, time
≈30 min
Molar ratio of EDTA/HAp for complete dissolution
≈ 300
Original publication
Dystrophic calcinosis: structural and morphological composition, and evaluation of ethylenediaminetetraacetic acid (‘EDTA’) for potential local treatment. Arthritis Res Ther. Published 22 May 2024. doi:10.
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