Systemic sclerosis & Raynaud's
Arthritis in patients with very early systemic sclerosis: a comprehensive clinical and prognostic analysis
Authors' conclusion
In this first comprehensive analysis, we found a similar prevalence of arthritis in veSSc as seen in established SSc.
Study context
- Population
- Patients with very early SSc (Raynaud's phenomenon (RP) and/or puffy fingers, antinuclear antibodies (ANA), abnormal capillaroscopy; not fulfilling ACR/EULAR SSc criteria at baseline)108 with follow-up
- Participants
- 159 patients
- Outcome
- Prevalence and phenotype of arthritis, and its prognostic impact (progression to established SSc)
Methodological detailslongitudinal analysis, multivariable Cox regression
- Longitudinal analysis
- Multivariable Cox regression
Main finding
As reported in the abstract
SSc-related arthritis at baseline (prevalence)
SSc-related arthritis at baseline
22 of 159
13.8%
Observational data: associations, not effects.
Further findings
Association of anti-centromere antibodies (ACA) with arthritis
| OR (95% CI) | P value | ||
|---|---|---|---|
| ACANegative association | 0.707 (0.513–0.973) | P = 0.033 | |
| 0.512Odds ratio (log scale) |
Progression to established SSc · observation time
- Patients with follow-up who progressed to established SSc
- 43/108 (39.8%)
- Arthritis not a significant predictor of progression in multivariable Cox regression
Original publication
Arthritis in patients with very early systemic sclerosis: a comprehensive clinical and prognostic analysis. Rheumatology (Oxford). Published 9 May 2024. doi:10.
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