Systemic sclerosis & Raynaud's
Comparison of serum exosome miRNA from patients with Raynaud's phenomenon with positive and negative serum antinuclear antibodies
Authors' conclusion
A comparative analysis of miRNAs contained within serum exosomes of patients with RP and negative ANA vs. samples from patients with RP and positive ANA identified several differentially expressed miRNAs that may represent non-invasive biomarkers to assist in the identification of patients with RP at risk of evolving into systemic sclerosis.
Study context
- Population
- Patients with Raynaud's phenomenon (RP) with negative or positive serum antinuclear antibodies (ANA)
- Exposure
- RP with negative ANA vs RP with positive ANA
- Outcome
- Differences in miRNA content of serum exosomes between the two cohorts
Methodological detailsNext Generation Sequencing of serum exosome miRNA, Serum exosomes isolated by polymer precipitation; MicroRNAs (miRNAs) identified by Next Generation Sequencing
- Next Generation Sequencing of serum exosome miRNA
- Serum exosomes isolated by polymer precipitation; miRNAs identified by Next Generation Sequencing
Main finding
As reported in the abstract
Serum exosome miRNAs with significant differences in content
- miRNAs with significant differences in content between ANA-negative RP and ANA-positive RP
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Observational data: associations, not effects.
Original publication
Comparison of serum exosome miRNA from patients with Raynaud's phenomenon with positive and negative serum antinuclear antibodies. Clin Exp Rheumatol. Published 1 August 2024. doi:10.
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