Systemic sclerosis & Raynaud's
Elevated neutrophil extracellular traps in systemic sclerosis-associated vasculopathy and suppression by a synthetic prostacyclin analog
Authors' conclusion
Our study demonstrates an association between NETs and vascular complications in SSc.
Study context
- Population
- Patients with systemic sclerosis (SSc) at a single academic medical center; vascular complications such as digital ulcers, PAH and scleroderma renal crisis
- Participants
- 125 patients
- Comparison
- SSc with vascular complications vs matched SSc without vascular complications; epoprostenol effect on NET release
- Diffuse cutaneous SScn = 87
- Limited cutaneous SScn = 38
- Outcome
- Association between circulating NETs and vascular complications
Methodological detailssingle academic medical center, in vitro and ex vivo assays
- Single academic medical center
- In vitro and ex vivo assays
Main finding
As reported in the abstract
- Neutrophil activation and NET release elevated in SSc with vascular complications vs matched patients without
- Neutrophil activation and NETs positively correlated with soluble E-selectin and VCAM-1 (circulating markers of vascular injury)
- Synthetic prostacyclin analog in patients with digital ischemia boosted neutrophil cyclic AMP, associated with blunted NET release and reduced circulating NETs
Original publication
Elevated neutrophil extracellular traps in systemic sclerosis-associated vasculopathy and suppression by a synthetic prostacyclin analog. Arthritis Res Ther. Published 25 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →