Association of the serum IgG glycosylation with disease activity of anti-transcription intermediary factor 1 gamma positive dermatomyositis
Authors' conclusion
Anti-TIF1γ positive DM presents a unique glycosylation pattern in serum IgG.
Study context
- Population
- Patients with dermatomyositis (DM), including anti-TIF1γ positive DM, disease controls and healthy controls
- Participants
- 52 / 46 / 49
- Exposure
- DM vs disease controls vs healthy controls
- DMn = 52
- Disease controls (DC)n = 46
- Healthy controls (HC)n = 49reference
- Outcome
- Glycosylation patterns of serum IgG and their clinical significance in anti-TIF1γ positive DM
Methodological detailslectin microarray, lectin blot validation
- Lectin microarray
- Lectin blot validation
Main finding
As reported in the abstract
Serum IgG glycan levels (lectin microarray and lectin blot)
- DM had significantly lower mannose and glucose glycan levels vs DC
- DM had significantly higher GalNAc, galactose, Galβ3GalNAc, sialic acid and fucose glycan levels vs HC
- Anti-TIF1γ positive DM had lower GlcNAc (LEL) glycan level vs myositis-specific autoantibodies (MSA) negative DM, DC and HC
Observational data: associations, not effects.
Further findings
Correlation of GlcNAc glycan level with clinical features
- Positive correlation with manual muscle test (r=0.547, p=0.028)
- Negative correlation with IL-6 level (r=−0.756, p=0.049)
- Negative correlation with disease activity score (r=−0.507, p=0.045)
Original publication
Association of the serum IgG glycosylation with disease activity of anti-transcription intermediary factor 1 gamma positive dermatomyositis. Clin Exp Rheumatol. Published 8 February 2022. doi:10.
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