Anti-transcription intermediary factor 1-gamma IgG2 isotype is associated with cancer in adult dermatomyositis: an ENMC multinational study
Main findingResult — go to the resultOdds ratio 2.26 95% CI 1.10–4.76Authors' conclusion
These results suggest considering anti-TIF1γ IgG2 ALBIA and IgG ELISA values as biomarkers of cancer in anti-TIF1 γ aAb-positive adult DM.
Study context
- Population
- Adults with DM (ENMC criteria) positive for anti-TIF1γ IgG auto-antibody (aAb) on serum sampled at DM diagnosis, with follow-up until cancer or ≥1 yearmean age 55±15 years
- Participants
- 132 adults
- Exposure
- DM with cancer vs DM without cancer
- Cancern = 72
- Outcome
- Association of anti-TIF1γ IgG2 aAb isotype with cancer
Methodological detailsinternational, multicentre
- International
- Multicentre
Main finding
As reported in the abstract
Odds ratio
2.26
95% CI 1.10–4.76
P = 0.026
Cancervs No cancer
OR 2.26 (95% CI 1.10–4.76); P = 0.026
Observational data: associations, not effects.
Further findings
Anti-TIF1γ IgG2 aAb ALBIA values
P = 0.042
Anti-TIF1γ IgG aAb ELISA values
P = 0.004
Original publication
Anti-transcription intermediary factor 1-gamma IgG2 isotype is associated with cancer in adult dermatomyositis: an ENMC multinational study. Rheumatology (Oxford). Published 17 October 2022. doi:10.
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