High prevalence of necrotising myopathy pattern in muscle biopsies of patients with anti-Jo-1 antisynthetase syndrome
Authors' conclusion
Our data show that almost 40% of patients with well-defined anti-Jo-1 ASSD with objective muscle impairment have a necrotising myopathy pattern in their muscle biopsies.
Study context
- Population
- Patients with anti-Jo-1 antisynthetase syndrome (ASSD) admitted for investigation of the disease, obligatorily with muscle impairment, 2010–2021
- Participants
- 26 patients
- Outcome
- Muscle histological pattern in muscle biopsies (serial frozen sections)
Main finding
As reported in the abstract
Muscle biopsy pattern
Necrotising myopathy pattern
38.5%
General inflammatory myopathy pattern
34.6%
Nonspecific myopathy
26.9%
Observational data: associations, not effects.
Further findings
Muscle biopsy features
- Cell infiltrates present
- 76.9%
- Infiltrates mainly at endomysium
- 70%
- Predominance of macrophages
- 92.9%
- Fiber muscle necrosis present
- 92.3%
- Necrosis diffused
- 54.2%
- MHC-I expression seen in all samples
- Mostly CD68+ with discreet/low CD4+ and CD8+ staining
Association of necrotising myopathy pattern with demographic, clinical or laboratory data
- Not associated with demographic, clinical, or laboratory data
Mean age at disease diagnosis
- Mean age at diagnosis (years), ±
- 42.8±11.6
- Female gender most predominant
Original publication
High prevalence of necrotising myopathy pattern in muscle biopsies of patients with anti-Jo-1 antisynthetase syndrome. Clin Exp Rheumatol. Published 5 January 2022. doi:10.
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