Efficacy and safety of plasma exchange in interstitial lung diseases with anti-melanoma differentiation-associated 5 gene antibody positive clinically amyopathic dermatomyositis
Authors' conclusion
Combination therapy with PE was associated with an improved survival rate, and may be effective for the management of refractory ILD in CADM patients.
Study context
- Population
- CADM-ILD patients refractory to combination therapy of high-dose GC, calcineurin inhibitors and CYC
- Participants
- 19 participants
- Comparison
- Plasma exchange (PE) added to combination therapy vs no PE in refractory CADM-ILD
- PEn = 11
- Outcome
- Survival rate
Main finding
As reported in the abstract
P < 0.05
Observational data: associations, not effects.
Further findings
Serological activity markers (anti-MDA-5 titre, ferritin, KL-6) in PE-treated patients
- Sustainably reduced only after initiating PE
Exacerbation of interstitial lung disease (ILD) requiring methylprednisolone pulse therapy
- PE reduced the frequency
Safety
Bacterial, fungal and cytomegalovirus infection
- Did not differ between groups with and without PE
Adverse events associated with PE
- Resolved with appropriate intervention
Original publication
Efficacy and safety of plasma exchange in interstitial lung diseases with anti-melanoma differentiation-associated 5 gene antibody positive clinically amyopathic dermatomyositis. Scand J Rheumatol. Published 13 December 2021. doi:10.
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