Progression prediction in idiopathic inflammatory myopathy-associated interstitial lung disease: a combination of initial high attenuation areas and anti-melanoma differentiation-associated gene 5-positive
Authors' conclusion
Among IIM patients, those who are anti-MDA5-positive, and exhibit HAA (>465.745cm3) are more likely to experience ILD progression.
Study context
- Population
- Patients with IIM-associated interstitial lung disease (ILD)
- Outcome
- ILD progression
Methodological detailsunivariate and multivariate Cox regression
- Univariate and multivariate Cox regression
Main finding
As reported in the abstract
Independent risk factors for ILD progression (multivariate Cox regression)
Hazard ratio (95% CI)P value
HAA (>465.745 cm³)
5.007(1.773–14.144)
P = 0.002Anti-MDA5 positivityreported by the authors as an autonomous prognostic risk factor
0.127(0.041–0.396)
P < 0.001Observational data: associations, not effects.
Further findings
Factors for ILD progression (univariate Cox regression)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Elevated carcinoembryonic antigen | 1.036 (1.004–1.069) | P = 0.027 | |
| PO2Protective factor | 0.980 (0.962–0.997) | P = 0.025 | |
| FVCProtective factor | 0.551 (0.320–0.946) | P = 0.031 | |
| Anti-EJ positivityReported by the authors as a risk factor | 0.399 (0.175–0.912) | P = 0.029 | |
| Anti-Ro52 positivityReported by the authors as a risk factor | 0.437 (0.199–0.960) | P = 0.039 | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
Progression prediction in idiopathic inflammatory myopathy-associated interstitial lung disease: a combination of initial high attenuation areas and anti-melanoma differentiation-associated gene 5-positive. Clin Exp Rheumatol. Published 31 August 2023. doi:10.
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