Identification of Three Different Phenotypes in Anti–Melanoma Differentiation–Associated Gene 5 Antibody–Positive Dermatomyositis Patients: Implications for Prediction of Rapidly Progressive Interstitial Lung Disease
Authors' conclusion
Cluster analysis identified 3 distinct clinical patterns and outcomes in our large cohort of anti-MDA5+ DM patients.
Study context
- Population
- Patients with anti-MDA5+ dermatomyositis (DM)retrospectively enrolled
- Participants
- 265 patients
- Exposure
- Three phenotype clusters of anti-MDA5+ DM
- Cluster 1n = 108
- Cluster 2n = 72
- Cluster 3n = 85
- Outcome
- Cumulative incidence of non-RPILD
Methodological detailsunsupervised hierarchical cluster analysis, decision tree analysis, external validation cohort
- Unsupervised hierarchical cluster analysis
- Decision tree analysis
- External validation cohort
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
All-cause mortality — Cluster 3 vs Cluster 2 · across clusters 3, 2 and 1
P < 0.0001
Decision tree classification algorithm (8 variables) accuracy
- Accuracy, development cohort
- 78.5%
- Accuracy, external validation cohort
- 70.0%
- Variables: age >50 years, disease course <3 months, myasthenia (proximal muscle weakness), arthritis, CRP, creatine kinase, anti-Ro 52 titer, anti-MDA5 titer
Original publication
Identification of Three Different Phenotypes in Anti–Melanoma Differentiation–Associated Gene 5 Antibody–Positive Dermatomyositis Patients: Implications for Prediction of Rapidly Progressive Interstitial Lung Disease. Arthritis Rheumatol. Published 17 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →