Peripheral blood immunophenotypic diversity in patients with anti-MDA5+ dermatomyositis and its impact on prognosis
Authors' conclusion
Lymphocytes and their subsets were significantly altered in anti-MDA5+ DM patients. There was remarkable heterogeneity of lymphocyte subsets in anti-MDA5+ DM patients between survivors and non-survivors. Anti-MDA5+ DM patients were divided into two groups with distinct symptoms and survival rate by cluster analysis based on lymphocyte subsets.
Study context
- Population
- Patients with anti-MDA5+ DM and gender-age matched healthy controls (HCs)
- Participants
- 268 / 536 / 125 / 143
- Exposure
- Anti-MDA5+ DM vs matched HCs; cluster 1 vs cluster 2
- Anti-MDA5+ DMn = 268
- HCsn = 536reference
- Cluster 1n = 125
- Cluster 2n = 143reference
- Outcome
- Peripheral blood lymphocyte subsets and clusters
Methodological detailsgender-age matched healthy controls, cluster analysis based on peripheral blood lymphocyte subsets
- Gender-age matched healthy controls
- Cluster analysis based on peripheral blood lymphocyte subsets
Main finding
As reported in the abstract
- RP-ILD rate, 3-month and 6-month death rate dramatically higher in cluster 1 than cluster 2
- p<0.001, respectively
Observational data: associations, not effects.
Original publication
Peripheral blood immunophenotypic diversity in patients with anti-MDA5+ dermatomyositis and its impact on prognosis. Clin Exp Rheumatol. Published 4 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →