Cardiac involvement in patients with anti-melanoma differentiation-associated gene-5 antibody-positive dermatomyositis
Authors' conclusion
Subclinical cardiac involvement was predominant in patients with MDA5-DM and can be sensitively detected by CMR.
Study context
- Population
- Patients with anti-MDA5 antibody-positive DM and age- and sex-matched healthy controls (HCs)
- Participants
- 37 vs 31
- Exposure
- MDA5-DM vs age- and sex-matched HCs; abnormal vs normal cardiac magnetic resonance (CMR) parameters
- MDA5-DMn = 37
- HCsn = 31reference
- Outcome
- Cardiac involvement assessed by ECG, echocardiography and cardiac MRI
Methodological detailsage- and sex-matched healthy controls, follow-up of 6 patients with abnormal CMR
- Age- and sex-matched healthy controls
- Follow-up of 6 patients with abnormal CMR
Main finding
As reported in the abstract
Cardiac involvement in MDA5-DM
- Chest pain
- 3
- Palpitations
- 9
- Sinus tachycardia and ST-T changes, incidence
- 13.5%
- Premature atrial/ventricular contractions
- 3
- Decreased LV systolic function on echocardiography
- 4
- Abnormal CMR mapping results
- 24
- Elevated extracellular volume
- 45.9%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Abnormal vs normal CMR parameters (subgroup analysis) | all p≤0.001 |
Risk factor for abnormal CMR (logistic regression)
- Cutaneous Visual Analog Scale (VAS) score a risk factor for abnormal CMR
- P = 0.033
CMR mapping after treatment (6 patients with abnormal CMR)
- Significantly improved CMR mapping parameters post-treatment
Original publication
Cardiac involvement in patients with anti-melanoma differentiation-associated gene-5 antibody-positive dermatomyositis. Clin Exp Rheumatol. Published 8 February 2025. doi:10.
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