Quantitative interstitial lung disease scores in idiopathic inflammatory myopathies: longitudinal changes and clinical implications
Authors' conclusion
QILD changes in IIMs-ILD were dynamic, and baseline UIP patterns seemed to be related to a longitudinal progression in QILD.
Study context
- Population
- Patients with IIM-related ILD who underwent serial high-resolution CT (HRCT) scans at least twicethree serial scans: n = 41
- Participants
- 80 patients
- Exposure
- Usual interstitial pneumonia (UIP) vs non-UIP
- Outcome
- Quantitative ILD (QILD) scores and their longitudinal changes
Methodological detailscomputer-aided quantitative HRCT analysis, serial HRCT scans
- Computer-aided quantitative HRCT analysis
- Serial HRCT scans
Main finding
As reported in the abstract
Baseline median Quantitative ILD (QILD) score, whole lung (IQR 19.1-43.8)
28.1%
Correlation of QILD with FVC (r)
−0.349
P = 0.002
Correlation of QILD with DLCO (r)
−0.381
P = 0.001
Observational data: associations, not effects.
Further findings
QILD aggravation between the first two scans, by visual ILD subtype
P = 0.013
Radiographic ILD progression (ΔQILD >2%), multivariable logistic regression
- UIP significantly related to radiographic ILD progression
- P = 0.015
Lung transplantation or death by baseline QILD
- Higher baseline QILD (>28.1%) had higher risk of lung transplantation or death
- P = 0.015
Dynamic ΔQILD over three serial HRCT scans (n = 41)
- Four distinct patterns observed: improving, worsening, convex and concave
Original publication
Quantitative interstitial lung disease scores in idiopathic inflammatory myopathies: longitudinal changes and clinical implications. Rheumatology (Oxford). Published 17 March 2023. doi:10.
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