The diagnostic value of urinary N-terminal fragment of titin for skeletal muscle damage in idiopathic inflammatory myopathy
Performance · Urinary N-titin for diagnosing skeletal muscle damage in IIMResult — go to the resultOdds ratio 1.035 95% CI 1.002–1.069Authors' conclusion
Urinary N-titin is a non-invasive and independent predictive factor for determining skeletal muscle damage in patients with IIM.
Study context
- Population
- Patients with IIM, patients with other CTD diseases and healthy controls
- Participants
- 62 / 59 / 29
- Comparison
- Urinary N-titin in IIM vs other CTD and healthy controls; IIM with vs without skeletal muscle injury
- IIMn = 62
- CTD controlsn = 59reference
- Healthy controlsn = 29reference
- Outcome
- Diagnostic value of urinary N-titin for skeletal muscle damage in IIM
Methodological detailsELISA, logistic regression, Spearman correlation
- ELISA
- Logistic regression
- Spearman correlation
Performance
As reported in the abstract
Urinary N-titin for diagnosing skeletal muscle damage in IIM
Odds ratio
1.035
95% CI 1.002–1.069
P = 0.039
By group
N-titin
- Cut-off (pmol/mg Cr)
- 89.9
- Sensitivity
- 87.8%
- Specificity
- 100%
- AUC
- 0.971 (95% CI: 0.938, 1.000, P < 0.001)
N-titin
Cut-off (pmol/mg Cr)89.9
Sensitivity87.8%
Specificity100%
AUC0.971 (95% CI: 0.938, 1.000, P < 0.001)
N-titin
OR 1.035 (95% CI 1.002–1.069); P = 0.039
Further findings
| Outcome | IIM | CTD controls | Healthy controls | P value |
|---|---|---|---|---|
| Urinary N-titin level (pmol/mg cr)IIM vs CTD controls and healthy controls · significantly higher in IIM | 168.3 (interval 19.0–1279.0) pmol/mg cr | 2.80 (interval 1.53–3.60) | 1.83 (interval 1.09–2.95) | P < 0.001 |
| Urinary N-titin in IIM with vs without skeletal muscle injury (subgroup)Significantly higher with injury | P < 0.001 |
- Urinary N-titin in IIM with vs without skeletal muscle injury (subgroup): With skeletal muscle injury 1001.0 (interval 181.8–1977.0)
- Urinary N-titin in IIM with vs without skeletal muscle injury (subgroup): Without skeletal muscle injury 9.3 (interval 5.8–23.9)
Correlation of N-titin with CK (Spearman)
- R with CK
- 0.907, P < 0.001
- Strongly correlated with muscle disease activity assessment scores
Original publication
The diagnostic value of urinary N-terminal fragment of titin for skeletal muscle damage in idiopathic inflammatory myopathy. Rheumatology (Oxford). Published 15 March 2023. doi:10.
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