Identification of key biomarkers associated with immune cells infiltration for myocardial injury in dermatomyositis by integrated bioinformatics analysis
Authors' conclusion
Our findings suggest that IFIT3, OAS3, ISG15, and RSAD2 may play crucial roles in the underlying mechanism of myocardial injury in DM. Serum miR-146a-5p could be a potential biomarker for myocardial injury in DM.
Study context
- Population
- Skeletal muscle specimens of dermatomyositis (DM) and myocardium specimens of myocarditis from Gene Expression Omnibus (GEO) datasets; clinical samples of DM
- Comparison
- DM with myocardial injury vs DM without myocardial injury (miR-146a-5p validation); DM and myocarditis vs healthy control
- Outcome
- Hub-genes enriched in the immune system process in DM and myocarditis, immune cell infiltration and gene enrichment
Methodological detailsintegrated bioinformatics analysis, public GEO datasets, WGCNA, differentially expressed genes (DEGs), protein-protein interaction (PPI) and gene ontology (GO) analysis, CIBERSORT immune cell infiltration, validation in online datasets and clinical samples
- Integrated bioinformatics analysis
- Public GEO datasets
- WGCNA, DEGs, PPI and GO analysis
- CIBERSORT immune cell infiltration
- Validation in online datasets and clinical samples
Main finding
As reported in the abstract
Hub-genes enriched in the immune system process identified in DM and myocarditis databases, respectively
10 and 5
Original publication
Identification of key biomarkers associated with immune cells infiltration for myocardial injury in dermatomyositis by integrated bioinformatics analysis. Arthritis Res Ther. Published 28 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →