Muscle-specific miRNAs in plasma and skeletal muscle of patients with idiopathic inflammatory myopathy are modulated by disease and training
Authors' conclusion
Lower myomiR levels in the skeletal muscle of IIM patients might indicate reduced muscle regenerative potential in IIM, which could be linked to inflammation, metabolic dysfunction, and immunosuppressive therapy. Training-induced changes in muscle and plasma myomiRs indicate an increase in the release of myomiRs, which could contribute to the adaptive response underlying the positive systemic effects of exercise in IIM.
Study context
- Population
- Patients with idiopathic inflammatory myopathy (IIM) and healthy controls; vastus lateralis muscle and plasma samplestraining subset n = 7
- Comparison
- IIM patients vs healthy controls; before vs after 6-month training in IIM
- Outcome
- MyomiR levels (miR-1, −206, −133a, −133b) in plasma and skeletal muscle by quantitative PCR (qPCR)
Methodological detailscase-control comparison, 6-month training intervention subset, in vitro muscle cell experiments
- Case-control comparison
- 6-month training intervention subset
- In vitro muscle cell experiments
Main finding
As reported in the abstract
- Muscle miR-133a, miR-1 and miR-206 not regulated
- IIM vs Healthy controls: P = 0.03
- IIM vs Healthy controls: P < 0.05
Further findings
Effect of 6-month training in IIM (n = 7)
- Training lowered miR-133b in muscle while increasing miR-133b and miR-206 in plasma
In vitro myotubes
- TNF, insulin, glucose and dexamethasone (individually) downregulated distinct myomiRs
Original publication
Muscle-specific miRNAs in plasma and skeletal muscle of patients with idiopathic inflammatory myopathy are modulated by disease and training. Rheumatology (Oxford). Published 7 January 2025. doi:10.
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