Occupational and Hobby Exposures Associated With Myositis Phenotypes in a National Myositis Patient Registry
Authors' conclusion
These findings, based on a systematic exposure assessment, suggest that occupational and hobby exposures to silica and heavy metals contribute to adult IIM phenotypes, including DM, OM, and LD+, a possible marker for antisynthetase syndrome or other autoantibody-associated lung diseases.
Study context
- Population
- Adults (≥18 years) with idiopathic inflammatory myopathy (IIM) from a national registry
- Participants
- 598 / 409 / 383 / 218 / 166
- Exposure
- Occupational and hobby exposures to silica, solvents and heavy metals; Dermatomyositis (DM), polymyositis (PM), LD+ and overlap myositis (OM) phenotypes vs inclusion body myositis (IBM) or no LD
- DMn = 598
- PMn = 409
- IBMn = 383reference
- LD+n = 218
- OMn = 166
- Outcome
- Odds of IIM phenotypes (DM, PM vs IBM; LD+; OM) by occupational and hobby exposure to silica, solvents and heavy metals
Methodological detailsnational registry, systematic exposure assessment, adjusted odds ratios (ORs), joint effects with smoking
- National registry
- Systematic exposure assessment
- Adjusted ORs
- Joint effects with smoking
Main finding
As reported in the abstract
Odds of IIM phenotype by exposure
Odds ratio (95% CI)P value
DM vs IBMhighvs no silica exposure
2.02(1.18–3.46)
P = 0.004for trendLD+vs no LDhigh silica exposure
1.75(1.10–2.78)
P = 0.005for trendOMvs IBMhigh silica exposure
2.07(1.19–3.61)
P = 0.020for trendLD+vs IBMmoderate to high heavy metals exposure
1.49(1.00–2.14)
P = 0.026for trendOMvs IBMmoderate to high heavy metals exposure
1.59(0.99–2.55)
P = 0.051for trendObservational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| LD+: smokers with moderate to high silica exposurevs nonsmokers with low or no exposure (joint effect)High-certainty assessment | 2.53 (1.31–4.90) | P for interaction = 0.061 | |
| 0.20.5125Odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Occupational and Hobby Exposures Associated With Myositis Phenotypes in a National Myositis Patient Registry. Arthritis Care Res (Hoboken). Published 30 December 2024. doi:10.
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