Infections preceding diagnosis associated with myositis phenotypes in a national patient registry
Authors' conclusion
Antecedent infections, particularly respiratory and gastrointestinal infections may contribute to adult IIM phenotypes. Pneumonia showed the strongest association with myositis phenotypes accompanied by frequent lung disease.
Study context
- Population
- Adult IIM patients enrolled in a national myositis patient registry
- Participants
- 362 / 250 / 256 / 134 / 103
- Exposure
- Antecedent infections across IIM subgroups and phenotypes
- Dermatomyositis (DM)n = 362
- Polymyositis (PM)n = 250
- Inclusion body myositis (IBM)n = 256reference
- LD+n = 134
- Overlap myositis (OM)n = 103
- Outcome
- Self-reported infections and antibiotic usage within 12 months prior to IIM diagnosis
- Follow-up
- 12 months prior to IIM diagnosis
Methodological detailsnational patient registry, self-reported infections, adjusted odds ratios (ORs)
- National patient registry
- Self-reported infections
- Adjusted ORs
Main finding
As reported in the abstract
Infections before IIM diagnosis
OR
- DM · febrile illness
- 2.82
- DM · gastroenteritis
- 3.30
- PM · febrile illness
- 3.27
- PM · gastroenteritis
- 3.26
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Pneumonia (most strongly associated infection) in LD+ and OM vs without phenotypeLD+vs IBMvs no LD; IBM excluded | 5.26 (2.59–10.71) | |
| Pneumonia (most strongly associated infection) in LD+ and OM vs without phenotypeOMvs IBMvs no OM; IBM excluded | 2.75 (1.25–6.06) | |
| 0.050.21520Odds ratio (log scale) |
Pneumonia (most strongly associated infection) in LD+ and OM vs without phenotype
- LD+ and OM had higher odds of reported infections than those without these phenotypes
Antibiotic usage within 1 year before diagnosis
- Did not differ among DM, PM and IBM, nor in OM
- More frequent in LD+ vs no LD, attenuated after adjusting for infections
Original publication
Infections preceding diagnosis associated with myositis phenotypes in a national patient registry. Clin Exp Rheumatol. Published 10 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →