Enhanced systemic oxidative stress response in patients with idiopathic inflammatory myopathies
Authors' conclusion
IIM are characterized by a global pro-oxidant imbalance reflected by enhanced HP generation in serum.
Study context
- Population
- Clinically stable patients with idiopathic inflammatory myopathies (IIM) (DM and myositis) and matched controls
- Participants
- 18 / 38 / 50
- Exposure
- IIM vs matched controls
- Dermatomyositisn = 18
- Myositisn = 38
- Controlsn = 50reference
- Outcome
- Global oxidative stress response in peripheral blood: protein hydroperoxide (HP) formation in serum by coumarin boronic acid (CBA) assay
Methodological detailsmatched controls
- Matched controls
Main finding
As reported in the abstract
Fluorescent product generation (HP formation), IIM vs control
- Kinetics 36% faster in IIM vs control
- p < 0.001
- Cumulative fluorescent product generation increased 68% in IIM vs control
- p = 0.003
Observational data: associations, not effects.
Further findings
Dynamics of fluorescent product growth, DM vs myositis
- Similar in the DM and myositis groups
Serum myoglobin in myositis patients with marked increase in hydroperoxides (HP) formation
- Lower serum myoglobin levels
- P = 0.038
Correlation of serum myoglobin with cumulative in-time HP generation
- Inverse correlation, r
- −0.35
- P
- P = 0.03
Oxidative stress measures vs clinical characteristics, treatment, comorbidities, smoking, autoantibody profile
- Not related
Original publication
Enhanced systemic oxidative stress response in patients with idiopathic inflammatory myopathies. Arthritis Res Ther. Published 7 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →