Vitamin D and its receptor in skeletal muscle are associated with muscle disease manifestation, lipid metabolism and physical fitness of patients with myositis
Authors' conclusion
Reduced biologically active vitamin D in circulation suggests its impaired metabolism in IIM.
Study context
- Population
- Patients with idiopathic inflammatory myopathies (IIM) and healthy controls; 27 IIM patients in a 24-week exercise intervention27 IIM in exercise intervention
- Participants
- 46 vs 67
- Exposure
- IIM patients vs healthy controls
- IIMn = 46
- Healthy controls (HC)n = 67reference
- Outcome
- Serum active 1,25(OH)D
Methodological details24-week exercise intervention, muscle biopsies before/after training
- 24-week exercise intervention
- Muscle biopsies before/after training
Main finding
As reported in the abstract
P < 0.0001
Observational data: associations, not effects.
Further findings
Correlations of 25(OH)D in IIM
- 25(OH)D vs CRP
- r = −0.316, p = 0.037
- 25(OH)D vs MITAX
- r = −0.311, p = 0.040
- 25(OH)D vs HAQ
- r = −0.390, p = 0.009
Correlations of active 1,25(OH)D after training · 24 weeks
- vs MMT8
- r = 0.866, p < 0.0001
- vs FI-2
- r = 0.608, p = 0.013
- vs HAQ
- r = −0.537, p = 0.032
Gene expression in primary muscle cells after training · 24 weeks
- VDR decreased
- P = 0.031
- CYP27B1 decreased
- P = 0.078
Correlations of muscle VDR mRNA
- vs MMT-8 (IIM)
- r = −0.559, p = 0.013
- vs serum CK (HC)
- r = 0.484, p = 0.031
- vs myoglobin (IIM)
- r = 0.510, p = 0.026
- vs myostatin (IIM)
- r = −0.519, p = 0.023
- VDR in differentiated muscle cells vs complete oxidation of palmitic acid
- r = −0.532, p = 0.028
Muscle CPT1 mRNA
- Downregulated in IIM
- P = 0.001
- Correlation with serum 1,25(OH) vitamin D
- r = 0.410, p = 0.042
Original publication
Vitamin D and its receptor in skeletal muscle are associated with muscle disease manifestation, lipid metabolism and physical fitness of patients with myositis. Arthritis Res Ther. Published 4 March 2025. doi:10.
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