Premature ageing in myositis: Impairments in physical function, muscle power and body composition
Authors' conclusion
Both myositis cohorts exhibited significant impairments in physical function, maximal muscle power and muscle mass compared to an age-matched healthy cohort, reflecting substantial deterioration and muscle deficit.
Study context
- Population
- Individuals with myositis (inclusion body myositis (IBM) or non-IBM idiopathic inflammatory myopathies (IIM)) and age- and sex-matched healthy controls
- Participants
- 22 / 32 / 1,305
- Exposure
- IBM and non-IBM IIM cohorts vs age- and sex-matched healthy cohort
- IBMn = 22
- Non-IBM IIMn = 32
- Healthyn = 1,305reference
- Outcome
- Physical function (30-s sit-to-stand), maximal leg extensor power and body composition (DEXA)
Methodological detailsage- and sex-matched healthy comparison cohort
- Age- and sex-matched healthy comparison cohort
Main finding
As reported in the abstract
Corresponding to values in healthy individuals ∼15-30 years older
Difference
∼ −50 to −70%
P < 0.05
IBM
Difference
∼ −17 to −36%
P < 0.05
Non-IBM IIM
Observational data: associations, not effects.
Further findings
| Outcome | Difference | P value |
|---|---|---|
| Arm-specific muscle index, males (subgroup)IBM vs Healthy | ∼ −17% | P < 0.05 |
| Leg-specific muscle index, males (subgroup)IBM vs Healthy | ∼ −12% | P < 0.05 |
| Arm-specific muscle and fat indices, females (subgroup)Non-IBM IIM vs Healthy | ∼ −11% | P < 0.05 |
- Arm-specific muscle index, males (subgroup): corresponding to levels in ∼15-20 years older healthy individuals
- Leg-specific muscle index, males (subgroup): corresponding to levels in ∼15-20 years older healthy individuals
- Arm-specific muscle and fat indices, females (subgroup): corresponding to values in healthy individuals ∼45 years older
Original publication
Premature ageing in myositis: Impairments in physical function, muscle power and body composition. Semin Arthritis Rheum. Published 13 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →