Plasma Proteome Reflects Tissue Damage and Clinical Manifestations in Patients With Inflammatory Myopathies
Authors' conclusion
Circulatory proteome is a promising tool to capture distinct tissue-specific responses that correlate with disease activity and tissue injury in patients with IIM.
Study context
- Population
- Patients diagnosed with idiopathic inflammatory myopathy (IIM) at Karolinska University Hospital
- Participants
- 201 patients
- Exposure
- Plasma proteome across IIM subtypes
- Outcome
- Differential plasma protein abundance and tissue scores across IIM subtypes
Methodological detailssingle-centre, proximity extension assay (Olink), plasma proteomics
- Single-centre
- Proximity extension assay (Olink)
- Plasma proteomics
Main finding
As reported in the abstract
- DM plasma enriched for interferon (IFN) signaling and skin-associated proteins
- Antisynthetase syndrome (ASyS) plasma enriched for lung-associated proteins; highest lung tissue scores
- Immune-mediated necrotizing myopathy (IMNM) plasma enriched for muscle-associated proteins; highest skeletal muscle tissue score
- IBM plasma enriched for T cell-response proteins
- Skeletal muscle scores correlated strongly with muscle disease activity VAS, creatine kinase and muscle weakness score
Observational data: associations, not effects.
Further findings
ILD with anti-MDA5 and anti-Jo1 autoantibodies
- Differential enrichment of surfactant proteins and IFN pathway activation
Original publication
Plasma Proteome Reflects Tissue Damage and Clinical Manifestations in Patients With Inflammatory Myopathies. Arthritis Rheumatol. Published 27 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →