Distinct cytokine and cytokine receptor expression patterns characterize different forms of myositis
Authors' conclusion
Each myositis clinical group and autoantibody subgroup had differentially overexpressed inflammatory mediators, including a strong type 1 inflammatory gene signature in IBM.
Study context
- Population
- Patients with different forms of myositis, other inflammatory or genetic myopathies, and controls with normal muscle tissue
- Participants
- 669 patients
- Exposure
- Myositis clinical groups and autoantibody subgroups vs all samples and vs normal tissue controls
- DMn = 105
- Immune-mediated necrotizing myopathy (IMNM)n = 80
- Anti-synthetase syndromen = 65
- IBMn = 53
- Anti-PM/Scl myositisn = 19
- Other myopathiesn = 310
- Normal tissue (NT)n = 37reference
- Outcome
- Group-specific differential expression of 338 genes encoding cytokines, cytokine receptors and immune checkpoints in muscle biopsies (α < 0.001)
Methodological detailsbulk RNA-sequencing of muscle biopsies
- Bulk RNA-sequencing of muscle biopsies
Main finding
As reported in the abstract
Differentially overexpressed cytokine, receptor and immune checkpoint genes
| Group | Value | IBM-specific genes |
|---|---|---|
| IBM | 71 differentially overexpressed genes | 37 |
IBM
Value71 differentially overexpressed genes
IBM-specific genes37
Observational data: associations, not effects.
Original publication
Distinct cytokine and cytokine receptor expression patterns characterize different forms of myositis. Rheumatology (Oxford). Published 20 June 2025. doi:10.
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