External validation of the 2017 EULAR/ACR classification criteria for idiopathic inflammatory myopathies in anti-MDA5 antibody-positive interstitial lung disease patients: A multicenter retrospective cohort study in China
Authors' conclusion
Approximately 30 % of clinically diagnosed anti-MDA5 antibody-positive IIM-ILD patients cannot be classified according to the EULAR/ACR criteria
Study context
- Population
- Adults with anti-MDA5 antibody-positive IIM-related ILD (dermatomyositis (DM) 23.6 %, clinically amyopathic dermatomyositis (CADM) 76.4 %), four hospitals in China
- Participants
- 250 adults
- Exposure
- 2017 EULAR/ACR IIM classification criteria vs Bohan/Peter criteria combined with Sontheimer's CADM criteria
- Outcome
- Performance of the 2017 EULAR/ACR classification criteria for classifying IIM
Methodological detailsmulticentre, external validation of classification criteria
- Multicentre
- External validation of classification criteria
Main finding
As reported in the abstract
Patients meeting classification criteria
| Group | Value | Sensitivity |
|---|---|---|
| EULAR/ACR criteria | 70 % | |
| Bohan/Peter criteria | 25.7 % | |
| Modified EULAR/ACR criteria | 99.2 % | |
| Casal-Domingez criteria | 100 % |
Value
EULAR/ACR criteria70 %
Bohan/Peter criteria25.7 %
Modified EULAR/ACR criteria— not stated in the abstract
Casal-Domingez criteria— not stated in the abstract
Sensitivity
EULAR/ACR criteria— not stated in the abstract
Bohan/Peter criteria— not stated in the abstract
Modified EULAR/ACR criteria99.2 %
Casal-Domingez criteria100 %
Observational data: associations, not effects.
Further findings
Classification by Bohan and Peter criteria according to Sontheimer's CADM criteria
- Patients classifiable
- 60.4 %
Not meeting EULAR/ACR criteria but meeting IPAF criteria
- Anti-MDA5+ patients
- Thirty percent
Clinical characteristics and prognoses
- No significant differences between patients meeting EULAR/ACR criteria, not meeting them, and meeting IPAF criteria
Original publication
External validation of the 2017 EULAR/ACR classification criteria for idiopathic inflammatory myopathies in anti-MDA5 antibody-positive interstitial lung disease patients: A multicenter retrospective cohort study in China. Semin Arthritis Rheum. Published 27 February 2025. doi:10.
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