Plasma levels of adhesion molecules are elevated in dermatomyositis-interstitial lung disease and associated with low paraoxonase-1 activity
Authors' conclusion
Plasma CAM levels were higher in DM patients compared to healthy controls, particularly in DM patients with ILD.
Study context
- Population
- Patients with dermatomyositis (DM) and DM-ILD and matched healthy controls; plasma samplesplasma samples analysed
- Participants
- 83 vs 28
- Exposure
- DM patients vs matched healthy controls
- DMn = 83
- Healthy controlsn = 28reference
- Outcome
- Circulating (plasma) ICAM-1 and VCAM-1 levels, measured by ELISA
Methodological detailsage and sex matched healthy controls, causal mediation analysis
- Age and sex matched healthy controls
- Causal mediation analysis
Main finding
As reported in the abstract
- Plasma CAM levels significantly higher in DM patients vs controls
- CAM levels particularly higher in anti-MDA5+ DM vs other autoantibody groups
- CAM levels higher in DM-ILD vs DM without ILD
Observational data: associations, not effects.
Further findings
- Proportion of effect of low lactonase on worse DLCO mediated through ICAM-1 (mediation analysis)
- 54%
- Higher ICAM-1 correlated with low PON1 lactonase activity and worse restrictive lung physiology in multivariate models
Original publication
Plasma levels of adhesion molecules are elevated in dermatomyositis-interstitial lung disease and associated with low paraoxonase-1 activity. Arthritis Res Ther. Published 8 March 2025. doi:10.
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