Cancer Risk and Mortality in Hospitalized Patients With Idiopathic Inflammatory Myopathies in Western Australia
Main finding · Prediagnosis cancer incidence rateResult — go to the resultRelative risk 1.11 95% CI 0.88–1.39Authors' conclusion
Cancer risk was not increased prior to IIM, but CIR for lung cancer was increased following DM diagnosis.
Study context
- Population
- Hospitalized patients with incident IIM in Western Australia, linked to Western Australia (WA) cancer and death registries, 1980 to 2014 (IIM: 56.5% female, median age 62.0 yrs)
- Participants
- 803 vs 3,225
- Exposure
- Hospitalized patients with incident IIM vs age-, sex-, and calendar year-matched controls
- IIMn = 803
- Controlsn = 3,225reference
- Outcome
- Cancer incidence rates before and after IIM diagnosis, and cancer mortality
Methodological detailspopulation-based linked administrative health data, age-, sex-, and calendar year-matched controls
- Population-based linked administrative health data
- Age-, sex-, and calendar year-matched controls
Main finding
Prediagnosis cancer incidence rate · before IIM diagnosis
Relative risk
1.11
95% CI 0.88–1.39
By group
IIM
6.57
Controls
5.95
IIMvs Controls
RR 1.11 (95% CI 0.88–1.39)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | |
|---|---|---|
| Prediagnosis CIR in patients evolving to DM (n = 220) or other IIM subtypes (subgroup) · before IIM diagnosisDM or other IIM subtypesvs Controls6.59 vs 6.56 | 1.01 (0.38–3.69) | |
| Lung cancer CIR after diagnosis, DMvs controls · follow-up1.05 vs 0.33 | 3.18 (1.71–5.47) | |
| 0.20.5125Relative risk (log scale) |
CIR during follow-up, all dermatomyositis (DM)
- CIR higher for all DM
- 4.05 (95% CI 3.04-5.29)
Life span with cancer post diagnosis
- Cancer post diagnosis shortened life span by 59 months for IIM (103 vs 162 months)
- P < 0.01
- Reduced survival rates observed only in DM and inclusion body myositis (IBM)
Original publication
Cancer Risk and Mortality in Hospitalized Patients With Idiopathic Inflammatory Myopathies in Western Australia. J Rheumatol. Published 1 February 2024. doi:10.
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