The longitudinal study of muscle changes with ultrasound: differential changes in idiopathic inflammatory myopathy subgroups
Authors' conclusion
SWE and US appear promising as imaging biomarkers for patient follow-up in IIM and indicate changes over time, especially with echogenicity, muscle bulk and SWS in the VL.
Study context
- Population
- Participants with idiopathic inflammatory myopathy (IIM) (immune-mediated necrotizing myopathy (IMNM) = 17, DM = 12, overlap myositis = 3, PM = 1); deltoid and vastus lateralis muscles
- Participants
- 33 participants
- Exposure
- Prevalent vs incident IIM groups, changes over time in shear wave elastography (SWE), B mode US and PDUS
- Prevalentn = 20
- Incidentn = 13
- Outcome
- Changes over time in SWS and US domains
Methodological detailsserial imaging on four occasions at intervals of 3-6 months
- Serial imaging on four occasions at intervals of 3-6 months
Main finding
As reported in the abstract
- Vastus lateralis (VL)-prevalent: echogenicity increased over time
- P = 0.040
- VL-incident: trend for reduction of echogenicity to normal over time with treatment
- P = 0.097
- D-prevalent: muscle bulk reduced over time, suggesting atrophy
- P = 0.096
- VL-incident: SWS reduced over time, suggesting trend towards improvement in muscle stiffness with treatment
- P = 0.096
Observational data: associations, not effects.
Original publication
The longitudinal study of muscle changes with ultrasound: differential changes in idiopathic inflammatory myopathy subgroups. Rheumatology (Oxford). Published 24 May 2023. doi:10.
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