Serum cytokine profiles of adults with idiopathic inflammatory myopathies
Authors' conclusion
This study demonstrated differences in cytokine profiles of IIM patients (active and inactive disease) compared to healthy controls and identified some cytokines that could potentially be used as biomarkers.
Study context
- Population
- Adults with idiopathic inflammatory myopathies (IIM) (active disease or in remission) and healthy controls
- Participants
- 21 / 11 / 10
- Exposure
- IIM with active disease vs IIM in remission vs healthy controls
- Active diseasen = 21
- Remissionn = 11
- Healthy controlsn = 10reference
- Outcome
- Serum concentrations of 51 cytokines/chemokines
Methodological detailsobservational, bead-based multiplex cytokine assay (Luminex®), Predictive cytokines assessed by LASSO modelling, stepwise approach and logistic regression
- Observational
- Bead-based multiplex cytokine assay (Luminex®)
- Predictive cytokines assessed by LASSO modelling, stepwise approach and logistic regression
Main finding
As reported in the abstract
Serum cytokine/chemokine levels
- Myositis patients vs healthy controls: elevated eotaxin, CXCL-9, IP-10, TNF-a, lymphotoxin-a, MMP-3, MMP-9 and IGFBP-2
- Active disease vs remission: higher lymphotoxin-a, CXCL-9, MIP-1a, MIP-1b and MMP-3
Observational data: associations, not effects.
Original publication
Serum cytokine profiles of adults with idiopathic inflammatory myopathies. Clin Exp Rheumatol. Published 19 May 2023. doi:10.
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