Characterising oesophageal motility disorders by high-resolution impedance manometry in dermatomyositis patients
Authors' conclusion
Interestingly, the MDA5-positive group had a higher burden of HRiM pathological findings, suggesting a greater severity of oesophageal involvement, often asymptomatic.
Study context
- Population
- Dermatomyositis (DM) patients (13 women, 2 men, age 54±15.2 years; mean disease duration 6.6 years), enrolled December 2021–December 202213 women and 2 men
- Participants
- 15 patients
- Exposure
- High-resolution impedance manometry (HRiM) oesophageal severity groups vs clinical and serological profiles
- G0n = 5reference
- G1n = 5
- G>1n = 5
- Outcome
- Association of HRiM severity groups with clinical and serological profiles
Main finding
As reported in the abstract
- G>1 significantly associated with MDA5 antibodies (80% vs. 20%)
- p<0.05
- DLCO < 80% present in 100% of G>1
- p<0.05
Observational data: associations, not effects.
Original publication
Characterising oesophageal motility disorders by high-resolution impedance manometry in dermatomyositis patients. Clin Exp Rheumatol. Published 14 May 2023. doi:10.
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