IFN-beta and EIF2AK2 are potential biomarkers for interstitial lung disease in anti-MDA5 positive dermatomyositis
Authors' conclusion
IFN-beta and EIF2AK2 contributed to the pathogenesis of MDA5+ DM-ILD, which could be used as potential therapeutic targets.
Study context
- Population
- Gene expression data of DM and non-specific interstitial pneumonia (NSIP) from the Gene Expression Omnibus (GEO) database; MDA5+ DM-ILD patients
- Comparison
- MDA5+ DM vs MDA5- DM vs NSIP
Methodological detailsbioinformatic analysis of GEO datasets, RT-qPCR and ELISA validation
- Bioinformatic analysis of GEO datasets
- RT-qPCR and ELISA validation
Main finding
As reported in the abstract
- Pathway 'herpes simplex virus 1 infection' up-regulated in both DM and NSIP (gene set enrichment analysis (GSEA))
- IFN-beta signalling pathway an important influencing factor in MDA5+ DM-ILD
- EIF2AK2 an important gene signature in MDA5+ DM-ILD (protein-protein interaction (PPI) analysis)
- Expression of IFN-beta and EIF2AK2 significantly increased in MDA5+ DM-ILD patients
Original publication
IFN-beta and EIF2AK2 are potential biomarkers for interstitial lung disease in anti-MDA5 positive dermatomyositis. Rheumatology (Oxford). Published 13 March 2023. doi:10.
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