Long non-coding RNA expression profiles in neutrophils revealed potential biomarker for rapidly progressive interstitial lung disease in MDA5+ dermatomyositis
Authors' conclusion
LncRNA expression profiling in neutrophils of MDA5+DM revealed differentially expressed lncRNAs. Lnc-ZCCHC13-18:1 has been identified as a possible biomarker for RPILD in MDA5+DM.
Study context
- Population
- Neutrophils from patients with MDA5+DM, Jo1+ASyS, MDA5-DM, SLE and healthy controlsRT-qPCR validation cohort
- Participants
- 280 participants
- Comparison
- MDA5+DM vs Jo1+ASyS, MDA5-DM, SLE and healthy controls
- MDA5+DMn = 103
- Jo1+ASySn = 85
- MDA5-DMn = 12
- SLEn = 26
- Healthy controlsn = 54reference
- Outcome
- Differentially expressed lncRNAs in neutrophils (RNA-Seq)
Methodological detailsRNA-Seq screening, RT-qPCR validation
- RNA-Seq screening
- RT-qPCR validation
Performance
As reported in the abstract
Up-regulated lncRNAs, MDA5+DM vs healthy controls
412
Down-regulated lncRNAs, MDA5+DM vs healthy controls
201
Up-regulated lncRNAs, MDA5+DM vs Jo1+ASyS
144
Down-regulated lncRNAs, MDA5+DM vs Jo1+ASyS
191
Further findings
Independent risk factors for RPILD in MDA5+DM
| OR (95% CI) | P value | ||
|---|---|---|---|
| Lnc-ZCCHC13-18:1 | 9.94 (2.71–47.12) | P = 0.001 | |
| Percentage of predicted diffusing capacity for carbon monoxide | 6.23 (1.88–24.29) | P = 0.004 | |
| Krebs von den Lungen-6 | 4.26 (1.31–15.63) | P = 0.02 | |
| Serum ferritin | 6.14 (1.75–26.41) | P = 0.008 | |
| Age at admission | 1.07 (1.01–1.13) | P = 0.031 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Long non-coding RNA expression profiles in neutrophils revealed potential biomarker for rapidly progressive interstitial lung disease in MDA5+ dermatomyositis. Clin Exp Rheumatol. Published 24 July 2025. doi:10.
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