Shared molecular profiles of anti-PL12 autoantibodies in anti-synthetase syndrome
Authors' conclusion
Anti-PL12 autoantibodies among different patients show highly convergent sequences and variable region composition.
Study context
- Population
- Patients with anti-PL12 autoantibodies identified from routine myositis immunoblots7 females · 3 males
- Participants
- 10 patients
- Outcome
- Anti-PL12 IgV subfamily expression and somatic hypermutation signatures by mass spectrometry (MS) sequencing
Methodological detailsmass spectrometry-based proteomics
- Mass spectrometry-based proteomics
Main finding
As reported in the abstract
Molecular profile of precipitating anti-PL12 IgGs
- Oligoclonal repertoire with shared expression of IGHV3-23-encoded heavy chain and IGKV3-20- and IGKV1-27-encoded light chains
- Shared IgV somatic hypermutations across unrelated patients in both heavy and light chain, in regions likely to be antigen interacting
Further findings
Clinical features
- Average age (years)
- 65
- Lung disease
- 10
- Concurrent myositis
- 2
- All had lung disease
Original publication
Shared molecular profiles of anti-PL12 autoantibodies in anti-synthetase syndrome. Rheumatology (Oxford). Published 9 July 2025. doi:10.
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