Alterations of mucosal-associated invariant T cells in dermatomyositis
Authors' conclusion
The reduced frequency of MAIT cells in DM may be associated with excessive activation. The increased secretion of IFN-γ by MAIT cells may contribute to DM pathogenesis.
Study context
- Population
- Untreated patients with dermatomyositis (DM) and healthy controls; peripheral blood mononuclear cells
- Participants
- 23 vs 32
- Exposure
- Untreated DM patients vs healthy controls
- DMn = 23
- Healthy controls (HC)n = 32reference
- Outcome
- Frequency of circulating MAIT cells
Methodological detailsflow cytometry
- Flow cytometry
Main finding
As reported in the abstract
- Frequency of circulating mucosal-associated invariant T (MAIT) cells significantly decreased in DM vs HC
- Proportion of CD69+ and PD-1+ MAIT cells significantly increased in DM, especially in MDA5-DM
- Expression of chemokine receptors CCR2 and CCR5 on MAIT cells reduced in DM
- Proportion of IFN-γ+ MAIT cells significantly elevated in DM
Observational data: associations, not effects.
Original publication
Alterations of mucosal-associated invariant T cells in dermatomyositis. Clin Exp Rheumatol. Published 5 July 2025. doi:10.
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