Health-related quality of life improvements and response thresholds of myositis outcome measures and response criteria
Authors' conclusion
Most CSMs and TIS in IIM significantly correlated with SF-36 domains, reflecting concurrent HRQoL improvements.
Study context
- Population
- Adults with idiopathic inflammatory myopathies (IIM) enrolled in two clinical trials and one observational study
- Participants
- 105 IIM patients
- Outcome
- Associations and improvement thresholds of myositis CSMs and TIS using SF-36
- Follow-up
- 6 months
Methodological detailspooled data from two clinical trials and one observational study, longitudinal, Spearman's correlation, mixed linear model, anchor-based minimal clinically important difference (MCID)
- Pooled data from two clinical trials and one observational study
- Longitudinal
- Spearman's correlation
- Mixed linear model
- Anchor-based MCID
Main finding
As reported in the abstract
- MCID for physician-global assessment (PhGA)
- 1.1
- MCID for patient-global assessment (PtGA)
- 1.84
- MCID for EXGLB
- 0.85
- MCID for Health Assessment Questionnaire (HAQ)
- 0.65
- MCID for manual muscle testing (MMT-8)
- 3.7
- MCID for Total Improvement Score (TIS)
- 23.7
Observational data: associations, not effects.
Original publication
Health-related quality of life improvements and response thresholds of myositis outcome measures and response criteria. Clin Exp Rheumatol. Published 1 July 2025. doi:10.
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