Protein kinase R is highly expressed in dermatomyositis and promotes interferon-beta-induced muscle damage
Authors' conclusion
We observed that PKR exhibits specific expression in the cytoplasm of DM muscle and inhibiting PKR ameliorates IFN-β-induced muscle damage in vitro.
Study context
- Population
- Consecutive dermatomyositis (DM) cohort and other diseases (muscle tissues); myoblasts and myotubes stimulated with IFN-β in vitro
- Outcome
- Diagnostic performance of sarcoplasmic PKR expression for DM
Methodological detailsbioinformatics analysis, retrospective diagnostic cohort, in vitro
- Bioinformatics analysis
- Retrospective diagnostic cohort
- In vitro
Main finding
As reported in the abstract
| Group | Sensitivity | Specificity |
|---|---|---|
| Sarcoplasmic protein kinase R (PKR) expression by immunohistochemistry (IHC) | 84.6% | 97.6% |
Sarcoplasmic protein kinase R (PKR) expression by immunohistochemistry (IHC)
Sensitivity84.6%
Specificity97.6%
Original publication
Protein kinase R is highly expressed in dermatomyositis and promotes interferon-beta-induced muscle damage. Ann Rheum Dis. Published 5 September 2024. doi:10.
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