Associations between 6-minute walk distance and physiologic measures and clinical outcomes in myositis-associated interstitial lung disease
Authors' conclusion
Exploratory work in a small cohort of MA-ILD demonstrated 6MWD over time associated with parallel changes in FVC and patient-reported outcomes of dyspnoea, but not with DLCO.
Study context
- Population
- Patients with anti-synthetase antibodies and active myositis-associated ILD (myositis-associated interstitial lung disease (MA-ILD)) in a 48-week trialmedian age 57 years
- Participants
- 20 patients
- Primary endpoint
- Associations between 6MWD and physiologic, clinical and radiographic parameters, cross-sectionally and longitudinally
Methodological detailsexploratory, multicentre, Spearman's correlations, repeated-measures linear mixed-effects models
- Exploratory
- Multicentre
- Spearman's correlations
- Repeated-measures linear mixed-effects models
Primary result
As reported in the abstract
Associations of 6MWD with other measures
- Baseline 6MWD did not associate with baseline pulmonary function tests
- 6MWD over time associated with forced vital capacity (FVC) over time, but not with DLCO
- 6MWD over time correlated with UCSD Shortness of Breath questionnaire dyspnoea score, Borg scores, global disease activity and muscle strength over time
- SF-36 emotional role functioning, vitality, general health and physical functioning scores correlated with 6MWD over time
Original publication
Associations between 6-minute walk distance and physiologic measures and clinical outcomes in myositis-associated interstitial lung disease. Rheumatology (Oxford). Published 2 September 2024. doi:10.
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