Relationship between high-resolution computed tomography quantitative imaging analysis and physiological and clinical features in antisynthetase syndrome-related interstitial lung disease
Authors' conclusion
Longitudinal QIA scores associate with lung physiology, patient perception of respiratory status, overall disease activity and quality of life over time in ARS-ILD.
Study context
- Population
- Patients with antisynthetase antibodies and active ILD (ASyS-ILD); median age 57 years, 55% males, 85% white
- Participants
- 20 patients
- Primary endpoint
- Association between extent of CT abnormalities by QIA (ground glass, QLF, QILD) and clinical/physiological disease parameters
- Follow-up
- Weeks 0, 24 and 48
Methodological detailslongitudinal, repeated-measures mixed-effects models
- Longitudinal
- Repeated-measures mixed-effects models
Primary result
As reported in the abstract
QIA scores vs clinical/physiological parameters
- Higher (worse) baseline quantitative imaging analysis (QIA) scores correlated with lower baseline forced vital capacity (FVC) and DLCO
- Longitudinal QIA scores strongly associated with both FVC and DLCO over time
- Higher QILD scores over time associated with worse dyspnoea scores, pulmonary VAS, physician and patient global disease activity, health status in 6/8 SF-36 domains and higher oxygen requirements
Further findings
Longitudinal QIA trajectories
- Trended towards improving scores during the trial; patients on O2 at baseline had worsening trajectories, different from those not on O2
Significant radiographic improvement · 48 weeks
- Patients with significant radiographic improvement had higher baseline QLF, QILD and worse DLCO
Original publication
Relationship between high-resolution computed tomography quantitative imaging analysis and physiological and clinical features in antisynthetase syndrome-related interstitial lung disease. RMD Open. Published 27 November 2024. doi:10.
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