Cross-sectional analysis of quantitative computed tomography parameters and pulmonary function in anti-synthetase syndrome-associated interstitial lung disease
Authors' conclusion
CT assessments in patients with ASyS-ILD demonstrate a progressive shift toward fibrotic patterns over time. Both CT scores and quantitative CT parameters are strongly associated with pulmonary function and reflect disease severity
Study context
- Population
- Newly diagnosed patients with ASyS-ILD positive for anti-synthetase antibodies with at least two chest computed tomography (CT) examinations (April 2014-December 2022)
- Participants
- 60 participants404 CT scans
- Exposure
- More advanced vs less advanced ASyS-ILD; clinical outcome groups
- Outcome
- Longitudinal CT features and correlation of quantitative CT with pulmonary function
- Follow-up
- Median 25 months
Methodological detailssemi-quantitative CT scoring, automated quantitative CT software
- Semi-quantitative CT scoring
- Automated quantitative CT software
Main finding
As reported in the abstract
median follow-up 25 months
- Traction bronchiectasis showed significant progression over time
- p<0.001
- Consolidation, pleural thickening and organising pneumonia (OP) patterns decreased significantly
- p<0.05
- Fibrotic patterns increased, anti-PL-12 subgroup
- 100%
- Fibrotic patterns increased, anti-Jo-1 subgroup
- 77.4%
- Fibrotic patterns increased, anti-EJ subgroup
- 77.8%
Observational data: associations, not effects.
Further findings
| Outcome | More advanced | Less advanced | P value |
|---|---|---|---|
| CT score | 13.0 ± 2.1 | 9.2 ± 2.4 | P < 0.001 |
| Mean lung density (MLD) | −696 ± 58 | −768 ± 61 | P = 0.001 |
| High-attenuation volume percentage (HAV%) | 6.3 ± 1.6 | 4.3 ± 2.1 | P = 0.002 |
| Low-attenuation volume percentage (LAV%) | 5.6 ± 8.0 | 11.3 ± 10.1 | P = 0.049 |
Baseline CT features by clinical outcome
- Traction bronchiectasis more frequent in stability and deterioration groups; OP pattern and consolidation more common in regression group
Original publication
Cross-sectional analysis of quantitative computed tomography parameters and pulmonary function in anti-synthetase syndrome-associated interstitial lung disease. Clin Exp Rheumatol. Published 13 August 2025. doi:10.
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