Human epididymitis protein 4 as a biomarker of interstitial lung disease in patients with idiopathic inflammatory myopathies
Authors' conclusion
HE4 might be a useful biomarker in the identification and assessment of ILD in IIMs patients.
Study context
- Population
- Consecutive IIM patients followed in one centre, June 2020–January 2023 (68% females, mean age 59.5 [52.75–66.0] years)plus 42 healthy controls
- Participants
- 90 patients
- Exposure
- Serum HE4 levels in IIM patients with vs without interstitial lung disease (ILD), and vs healthy controls
- IIMs-ILDn = 44
- Controlsn = 42
- Outcome
- Serum HE4 levels as potential biomarker of ILD
Methodological detailssingle-centre, consecutive enrolment, age- and sex-matched healthy controls, 2-year follow-up for PF-ILD
- Single-centre
- Consecutive enrolment
- Age- and sex-matched healthy controls
- 2-year follow-up for PF-ILD
Main finding
As reported in the abstract
Serum HE4 levels, IIMs-ILD vs without ILD
P < 0.0001
Observational data: associations, not effects.
Further findings
Serum HE4 independently associated with IIMs-ILD (multivariate analysis)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Serum HE4 | 1.063 (1.02–1.108) | P = 0.004 | |
| Serum HE4 | 1.059 (1.020–1.099) | P = 0.003 | |
| 0.512Odds ratio (log scale) |
pmol/L
| Outcome | IIMs-ILD | Controls | Estimate | P value |
|---|---|---|---|---|
| Serum HE4, IIMs vs controls | 78.55 (IQR 54.6–114.4) | 51.05 (IQR 41.8–62.8) | P = 0.001 | |
| Correlation of serum HE4 with DLCO and total lung capacitySerum HE4 | rho with DLCO −0.556 | P < 0.0001 | ||
| Correlation of serum HE4 with DLCO and total lung capacitySerum HE4 | rho with total lung capacity −0.459 | P = 0.001 |
- Serum HE4 independently associated with IIMs-ILD (multivariate analysis): two models of multivariate analysis; HE4 the only variable independently associated with IIMs-ILD
PF-ILD (INBUILD criteria) in IIMs-ILD with available follow-up · 2-year follow-up
- PF-ILD in IIMs-ILD with available follow-up (33/44)
- 39.4%
- No significant association with baseline serum HE4
Original publication
Human epididymitis protein 4 as a biomarker of interstitial lung disease in patients with idiopathic inflammatory myopathies. Clin Exp Rheumatol. Published 10 June 2024. doi:10.
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