Anti-FHL1 autoantibodies in adult patients with myositis: a longitudinal follow-up analysis
Authors' conclusion
Anti-FHL1 autoantibodies were present in 27% of patients with IIM; of these, 25% were negative for other autoantibodies. Other autoimmune diseases had lower frequencies and levels. Anti-FHL1 levels often decreased with immunosuppressive treatment, correlated with disease activity measures at diagnosis and rarely appeared after start of treatment.
Study context
- Population
- Adults with idiopathic inflammatory myopathies (IIM) and control groups; sera at time of diagnosis
- Participants
- 449 / 130 / 16 / 100
- Exposure
- IIM vs autoimmune disease controls, neuromuscular diseases and healthy controls
- IIMn = 449
- Disease controls (DC)n = 130reference
- NMDn = 16reference
- Healthy controls (HC)n = 100reference
- Outcome
- Prevalence of anti-FHL1 autoantibodies
- Follow-up
- Diagnosis
Methodological detailslongitudinal follow-up, enzyme-linked immunosorbent assay (ELISA)
- Longitudinal follow-up
- ELISA
Main finding
As reported in the abstract
Anti-FHL1 autoantibody frequency
IIM vs DC + NMD: P < 0.001 · IIM vs HC: P < 0.001
Observational data: associations, not effects.
Further findings
Median
| Outcome | IIM | DC | NMD | HC |
|---|---|---|---|---|
| Anti-FHL1 levels · diagnosis | 0.62 (IQR 0.15–1.04) | 0.22 (IQR 0.08–0.58) | 0.48 (IQR 0.36–0.80) | 0.35 (IQR 0.23–0.47) |
- Anti-FHL1 levels — Higher in IIM than DC, HC and NMD
- P < 0.001
- Anti-FHL1+ at baseline turned negative: Anti-FHL1+ 60%
- Anti-FHL1+ at baseline turned negative: denominator 33
Anti-FHL1+ vs anti-FHL1- IIM: age at diagnosis
- Anti-FHL1+ younger
- P = 0.05
- Anti-FHL1+ seronegative for other autoantibodies
- 25%
Anti-FHL1+ at baseline turned negative · first follow-up
- Anti-FHL1 autoantibodies rarely appeared after initiating treatment
Correlation of anti-FHL1 levels with disease activity · baseline
- CK, r = 0.62
- P = 0.01
- MYOACT (n = 14)
- P = 0.004
- MMT-8 (inverse), r = −0.59
- P = 0.02
Original publication
Anti-FHL1 autoantibodies in adult patients with myositis: a longitudinal follow-up analysis. Rheumatology (Oxford). Published 4 June 2024. doi:10.
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