Prevalence and functional characterization of anti-interferon autoantibodies in inflammatory myopathies
Authors' conclusion
A subset of patients with inflammatory myopathies harbour low-level anti-IFN autoantibodies, but the absence of functional activity suggests that these autoantibodies are unlikely to directly contribute to disease pathogenesis.
Study context
- Population
- Patients with myositis (inflammatory myopathies) from two independent cohorts, plus a validation cohort of 34 patients
- Participants
- 147 patients2 cohorts
- Outcome
- Prevalence and functional impact of anti-IFN autoantibodies
Methodological detailstwo independent cohorts, independent validation cohort, functional assays
- Two independent cohorts
- Independent validation cohort
- Functional assays
Main finding
As reported in the abstract
Increased binding to IFNs (anti-IFN autoantibodies), prevalence
IFN-α
3.9%
IFN-β
5.5%
IFN-ω
2.8%
IFN-γ
0.7%
Observational data: associations, not effects.
Further findings
Prevalence across myositis subtypes
- Prevalence did not significantly differ among myositis subtypes
Functional inhibition of type I IFN signalling
- No relevant inhibitory effects on type I IFN signalling
Original publication
Prevalence and functional characterization of anti-interferon autoantibodies in inflammatory myopathies. Rheumatology (Oxford). Published 6 August 2025. doi:10.
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