Comparison of pulmonary and small airways function between idiopathic inflammatory myopathies patients with and without interstitial lung disease
Authors' conclusion
Discrepancies between lung volumes measured by multiple breath nitrogen washout and body plethysmography in IIM-ILD patients indicate an early small airways dysfunction in these patients.
Study context
- Population
- Newly diagnosed idiopathic inflammatory myopathies (IIM) patients with and without interstitial lung disease (ILD)
- Participants
- 26 participants
- Exposure
- IIM with ILD vs IIM without ILD
- IIM-ILDn = 13
- IIM without ILDn = 13reference
- Outcome
- Pulmonary and small airway function (spirometry, DLCO, body plethysmography, single and multiple breath nitrogen washout, impulse oscillometry, resistance by the interrupter technique (Rint))
Main finding
As reported in the abstract
- Classic spirometric parameters and most lung physiology parameters assessing small airway function did not differ between the two groups
Observational data: associations, not effects.
Further findings
| Outcome | IIM-ILD | IIM without ILD | P value |
|---|---|---|---|
| Predicted TLC measured by multiple breath nitrogen washout (TLCN2WO)Significantly lower in IIM-ILD · mean | 111.1% | 153.4% | P = 0.034 |
| Predicted RV measured by multiple breath nitrogen washout (RVN2WO)Significantly lower in IIM-ILD · median | 171% | 210% | P = 0.039 |
| TLCN2WO/TLCpleth ratioSignificantly lower in IIM-ILD · median | 1.28 | 1.45 | P = 0.039 |
| Rint (respiratory resistance, interrupter technique)Tended to be higher in IIM-ILD · mean | 100.5% | 76.6% | P = 0.053 |
Original publication
Comparison of pulmonary and small airways function between idiopathic inflammatory myopathies patients with and without interstitial lung disease. Clin Exp Rheumatol. Published 26 March 2023. doi:10.
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