Association Between HLA Alleles and Autoantibodies in Dermatomyositis Defined by Sarcoplasmic Expression of Myxovirus Resistance Protein A
Authors' conclusion
This study demonstrates DM-specific autoantibodies defined immunogenetic subsets of DM.
Study context
- Population
- Japanese patients with dermatomyositis (DM) diagnosed by muscle pathology (sarcoplasmic MxA expression); 83 males, 92 females; range 1–86 yrs; mean 46 yrs83 males and 92 females
- Participants
- 175 patients
- Comparison
- Patients with DM (MxA-defined) vs healthy controls, stratified by DM-specific autoantibodies
- DMn = 175
- Outcome
- Associations of HLA alleles with 5 DM-specific autoantibodies
Methodological detailsHLA genotyping, multiple testing correction
- HLA genotyping
- Multiple testing correction
Main finding
As reported in the abstract
HLA allele associations in DM subsets by autoantibody
Odds ratio
28.9
corrected P = 2.7 × 10-6
DRB1*04:07
Odds ratio
4.0
corrected P = 1.6 × 10-4
DQB1*06:01
Observational data: associations, not effects.
Further findings
Patients with 1 of the 5 DM-specific autoantibodies
- Patients with 1 of the 5 autoantibodies
- 173 (98.9%)
Alleles more frequent in DM than healthy controls (A*02:07, B*46:01, DRB1*04:07, DRB1*07:01, DRB1*08:03, DQB1*06:01, DPB1*02:02)
- Associations not significant after multiple testing correction
Alleles associated with DM subsets stratified by DM-specific autoantibodies
- Already known alleles associated with subsets of DM
- 6
- New alleles associated with subsets of DM (B*48:01, B*52:01, C*12:02, DRB1*04:05, DRB1*15:02, DPB1*05:01, DPB1*09:01)
- 7
Original publication
Association Between HLA Alleles and Autoantibodies in Dermatomyositis Defined by Sarcoplasmic Expression of Myxovirus Resistance Protein A. J Rheumatol. Published 15 June 2023. doi:10.
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