Risk factors for mortality in patients with anti-MDA5 antibody-positive dermatomyositis: A meta-analysis and systematic review
Authors' conclusion
Old age, male sex, hypoxemia, low forced vital capacity, lymphocytopenia, and high levels of ferritin, CRP, creatine kinase, and LDH are risk factors for mortality in patients with MDA5+ DM.
Study context
- Population
- Patients with anti-MDA5 antibody-positive DM (MDA5+ DM); studies in Medline, Embase and Cochrane Library published before August 23, 2022
- Participants
- 2,645 patients29 cohorts
- Outcome
- Prognostic factors for mortality
Methodological detailspooled analysis of hazard ratios (HRs) or ORs
- Pooled analysis of HRs or ORs
Pooled result
As reported in the abstract
Prognostic factors for mortality (HR)
- Old age: HR 1.54, 95% CI 1.41-1.69
- p < 0.01
- Male sex: HR 2.07, 95% CI 1.34-3.18
- p < 0.01
- Rapidly progressive interstitial lung disease (RP-ILD): HR 9.34, 95% CI 6.39-13.6
- p < 0.01
- High ferritin: HR 1.05, 95% CI 1.01-1.08
- p < 0.01
- High C-reactive protein (CRP): HR 1.12, 95% CI 1.06-1.19
- p < 0.01
- High creatine kinase: HR 1.05, 95% CI 1.03-1.07
- p < 0.01
- High lactate dehydrogenase (LDH): HR 1.27, 95% CI 1.12-1.45
- p < 0.01
- Oxygen index (better outcomes): HR 0.990, 95% CI 0.988-0.992
- p < 0.01
- Partial pressure of oxygen (better outcomes): HR 0.933, 95% CI 0.906-0.961
- p < 0.01
- FVC (better outcomes): HR 0.962, 95% CI 0.928-0.998
- p = 0.038
- Lymphocyte count (better outcomes): HR 0.421, 95% CI 0.282-0.629
- p < 0.01
Original publication
Risk factors for mortality in patients with anti-MDA5 antibody-positive dermatomyositis: A meta-analysis and systematic review. Semin Arthritis Rheum. Published 9 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →