Predictors of rapidly progressive interstitial lung disease in anti-MDA5 dermatomyositis: a meta-analysis
Authors' conclusion
This meta-analysis identified multiple clinical and laboratory parameters as significant predictors of RP-ILD progression in MDA5+DM patients.
Study context
- Population
- Patients with anti-MDA5 antibody-positive DM (MDA5+DM); studies in PubMed, Embase, Web of Science and Cochrane Library published before December 2024
- Participants
- 2,579 patients27 cohorts
- Comparison
- MDA5+DM with rapidly progressive interstitial lung disease (RP-ILD) vs without RP-ILD
- Outcome
- Predictors for the development of RP-ILD in MDA5+DM
Methodological detailsTwo reviewers extracted data and assessed risk of bias
- Two reviewers extracted data and assessed risk of bias
Pooled result
As reported in the abstract
Predictors of RP-ILD
- Clinical predictors of RP-ILD: advanced age, male sex, fever, skin ulcers and arthritis
- Significantly elevated in RP-ILD: CRP, lactate dehydrogenase (LDH), AST, ferritin, ESR, leukocytes, KL-6, ALT, cartilage glycoprotein 39, positive anti-Ro52 antibodies and high-titre anti-MDA5 antibodies
- Significantly reduced in RP-ILD: lymphocytes, albumin, PaO2/FiO2 ratio and CD3+CD4+ T cell count
Original publication
Predictors of rapidly progressive interstitial lung disease in anti-MDA5 dermatomyositis: a meta-analysis. Rheumatology (Oxford). Published 23 June 2026. doi:10.
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