Gastrointestinal involvement in dermatomyositis: multicentric retrospective cohort study
Main finding · Severe GI involvement, monocentric DM cohortResult — go to the resultHazard ratio 8.85 95% CI 1.62–48.35Authors' conclusion
Severe GI involvement represents a life-threatening complication in DM and is mainly associated with anti-NXP2 antibody. In anti-NXP2 DM, young age and facial oedema are associated with severe GI involvement.
Study context
- Population
- Patients with DM: retrospective monocentric DM cohort and retrospective multicentric anti-NXP2 DM cohortplus multicentric anti-NXP2 cohort n = 48
- Participants
- 119 patients
- Exposure
- Anti-NXP2 DM vs other DM subgroups
- Outcome
- Prevalence of severe GI involvement (any symptomatic GI lesion, excluding isolated dysphagia, requiring surgery and/or ICU admission)
Methodological detailsmonocentric DM cohort, multicentric anti-NXP2 DM cohort
- Monocentric DM cohort
- Multicentric anti-NXP2 DM cohort
Main finding
Severe GI involvement, monocentric DM cohort
Hazard ratio
8.85
95% CI 1.62–48.35
By group
Anti-NXP2vs Other DM subgroups
HR 8.85 (95% CI 1.62–48.35)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Age in anti-NXP2 patients with vs without severe GI involvement | P < 0.01 |
| Facial oedema at diagnosis in anti-NXP2 patients with vs without severe GI involvement | P = 0.03 |
- Severe gastrointestinal (GI) involvement, multicentric anti-NXP2 cohort (incl. four digestive perforations and three digestive haemorrhages)
- 12.5%
- Concomitant skin and/or muscle disease activity at time of GI involvement, anti-NXP2
- 78%
- Age in anti-NXP2 patients with vs without severe GI involvement: Severe GI involvement median 24.5 years
- Age in anti-NXP2 patients with vs without severe GI involvement: No severe GI involvement median 42.5 years
- Facial oedema at diagnosis in anti-NXP2 patients with vs without severe GI involvement: Severe GI involvement 83%
- Facial oedema at diagnosis in anti-NXP2 patients with vs without severe GI involvement: No severe GI involvement 33%
Deaths
- No deaths were reported
Original publication
Gastrointestinal involvement in dermatomyositis: multicentric retrospective cohort study. Rheumatology (Oxford). Published 17 June 2026. doi:10.
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